This is why interferon, and most likely therapeutic vaccines, can cause hepatic decompensation in patients who have already developed cirrhosis of the liver. 这就是为什么干扰素，还有治疗性疫苗可能也是如此，在肝硬化病人中会引发肝失代偿。
The jaundice may fluctuate in a certain range, accompanied by itchy skin, weight loss, poor spirit.The ascites, oliguria and hepatic coma may occurr late due to liver failure. 少数病人抗核抗体及抗平滑肌抗体可为阳性，但抗线粒体抗体阴性，这可与原发性胆汁性肝硬化区别。
